Fund profile / United States

Red Tree Venture Capital Fund II

Geography: United States
Stage: Pre-Seed
Fund size: $133M
Focus: Deep Tech, Enterprise Software and SaaS
Signals: Published

N°01 / About

About Red Tree Venture Capital Fund II

Red Tree Venture Capital Fund II is a venture capital firm based in United States, focusing on Pre-Seed stage investments. The fund actively supports founders building innovative solutions in Deep Tech, Enterprise Software, SaaS, providing strategic guidance and capital to help startups scale.

N°02 / Thesis

Investment Focus

Location / RegionUnited States

Funding StagePre-Seed

Industry Focus

Deep Tech

Enterprise Software

SaaS

Investor Signals Profile

active

Sweet Spot

Academic biotech founders in immunology, oncology, or neurology

immunology

oncology

neurology

academic founders

biotech seed

Bullish Signals

Excellergy acquired by Novartis for $2Bexternal

Seeded at $5M, 58% stake — massive returnexternal

SAB network provides proprietary deal flowexternal

Portfolio co raised $70M Series Aexternal

SAB member sourced deal pre-company formationlinkedin

Guided strategy from day one — deep board controllinkedin

Tranched seed + 58% ownership — capital efficient entrylinkedin

Dr. Kari Nadeau SAB — top food allergy expertlinkedin

Beyond symptom management — immune disarming approachlinkedin

Excellergy founders: Eggel, Jardetzky, Pennington, Harrislinkedin

Novartis Excellergy acquisition validates immunology thesislinkedin

Todd Zavodnick CEO leadership drove successful executionlinkedin

Red Tree board guided strategy to Novartis winlinkedin

Contrarian Signals

Highly network-gated, SAB-driven accessexternal

Very early stage — high binary riskexternal

Founder Do's

Come from academic/scientific background

Work in immunology, oncology, or neurology

Engage scientific advisors early

Show best-in-class therapeutic differentiation

Accept tranched seed structure

Founder Don'ts

Skip clinical unmet need framing

Avoid symptom-only treatment approaches

Come without scientific advisory network

27 signals on Red Tree Venture Capital Fund II

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Facts

Fund Overview

Fund Size$133M

Saves0

Website

People

Key People

Heath Lukatch

Heath LukatchManaging Partner

Jennifer CochranBoard Member

Mike DybbsBoard Member

Dayton MisfeldtBoard Member

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