Fund profile / Italy

Claris Biotech II

Geography: Italy
Stage: Pre-Seed
Fund size: €100M
Focus: Biotech, Deep Tech and SaaS
Signals: Published

N°01 / About

About Claris Biotech II

Claris Biotech II is a venture capital firm based in Italy, focusing on Pre-Seed stage investments. The fund actively supports founders building innovative solutions in Biotech, Deep Tech, SaaS, providing strategic guidance and capital to help startups scale.

N°02 / Thesis

Investment Focus

Location / RegionItaly

Funding StagePre-Seed

Industry Focus

Biotech

Deep Tech

SaaS

Investor Signals Profile

active

Sweet Spot

Early-stage biopharma with clear vision, solid science

early-stage biopharma

oncology

rare diseases

immunology

RNA & CNS therapies

obesity

respiratory

cardiac regeneration

Bullish Signals

11 portfolio companies across biopharmaexternal

EU Horizon 2020 & EFSI backed fundexternal

EIF AlpGIP & Pan-European Guarantee Fund supportexternal

Oncology, RNA, CNS, immunology coverageexternal

Active EIR signals co-building capacitywebsite

Respiratory, cardiac, metastasis — broad bio coveragewebsite

11 named portfolio companies confirmed livewebsite

Haptena added — immuno-oncology expansionwebsite

Obesity & metabolic diseases added to focus areaswebsite

Resalis obesity ncRNA platform signals expansionwebsite

Capital, competence, hands-on clinical dev supportwebsite

Kither respiratory, NeoPhore immunotherapy, Page metastasiswebsite

Lever Bio tumor microenvironment reprogramming platformwebsite

TCR, small-molecule degraders, transcription factor silencingwebsite

InnovFin Equity backing, EU Horizon 2020 confirmedwebsite

ALKemist Bio TCR + Sibylla degrader platformswebsite

Contrarian Signals

Narrow biopharma-only mandateexternal

Italy-based, European deal focusexternal

No exits publicly visible yetexternal

Founder Do's

Show solid scientific evidence upfront

Address strong unmet clinical need

Focus on rare disease, oncology, immunology

Be ready for hands-on clinical dev support

Seek EU-backed capital partnerships

Founder Don'ts

No digital health or non-biopharma pitches

No pre-scientific or idea-stage companies

No markets without life-threatening indication

41 signals on Claris Biotech II

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Facts

Fund Overview

Fund Size€100M

Saves0

Website

People

Key People

Ciro Spedaliere, Ietro Uglisi

Pietro PuglisiManaging Partner

Ciro SpedaliereManaging Partner

Giulia VestriPartner

Paolo VigoInvestment Manager

Gianmarco PallaviciniSenior Associate

Giuditta MagnificoAssociate

Raffaele TroyaFinance & Administration Manager

Araceli AlbanoInternal Accounting & Administration

Roberto De PontiSenior Advisor

Laura Iris FerroSenior Advisor

Manilo MaroccoSenior Advisor

Michael HodgesEntrepreneur in Residence

Luca MelindoAdvisor

Cristina TumiattiIndependent Director

N°04 / See also

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