Fund profile / United States

Catalio Nexus Fund IV

Geography: United States
Stage: Pre-Seed
Fund size: $400M
Focus: Deep Tech and SaaS
Signals: Published

N°01 / About

About Catalio Nexus Fund IV

Catalio Nexus Fund IV is a venture capital firm based in United States, focusing on Pre-Seed stage investments. The fund actively supports founders building innovative solutions in Deep Tech, SaaS, providing strategic guidance and capital to help startups scale.

N°02 / Thesis

Investment Focus

Location / RegionUnited States

Funding StagePre-Seed

Industry Focus

Deep Tech

SaaS

Investor Signals Profile

active

Sweet Spot

Enterprise SaaS + rare disease biotech founders building asymmetric solutions

Enterprise AI

Legacy modernization

Knowledge management

SaaS tooling

Digital transformation

Biotech AI

Clinical imaging

Pulmonary disease imaging

Fast implementation

Rare disease

p53 oncology

Neurodegeneration

Bullish Signals

3 Fortune 500 CIOs on advisory boardexternal

40% faster migrations — early adopter dataexternal

90% AI code gen accuracy claimedexternal

Native connectors: Salesforce, ServiceNow, NetSuiteexternal

NOETIK GSK 5-year oncology partnership dealcatalio_linkedin

Clinical imaging AI selecting trial patientscatalio_linkedin

Avalyn Phase 2b: 70% fibrosis stabilized/reversedcatalio_linkedin

150+ patient imaging dataset, 5-year lung function holdcatalio_linkedin

Automata: 3-week deployment vs 15-month cyclescatalio_linkedin

Software-first design, show-not-tell enterprise tractioncatalio_linkedin

Octant: autosomal dominant blindness, unmet rare diseasecatalio_linkedin

Octant: p53 correctors cancer, neurodegeneration pipelinescatalio_linkedin

Octant CEO: principled bets on uncompetitive marketscatalio_linkedin

Contrarian Signals

Metrics based on early adopters onlyexternal

No named VC backers disclosedexternal

Advisory-heavy, no listed founding teamexternal

Founder Do's

Target enterprise legacy system pain

Show AI-powered automation metrics

Highlight migration speed & accuracy

Lead with institutional knowledge loss

Have enterprise security story ready

Demonstrate pharma/biotech AI partnerships

Show imaging AI clinical trial validation

Prove 3-week deployment cycles, not 15 months

Demo-first, conversation-second approach

Build what competitors won't tackle (rare disease, p53)

Founder Don'ts

Don't pitch generic documentation tools

Don't ignore compliance/security requirements

Don't skip migration ROI proof points

Don't rely on long sales cycles

Don't pursue me-too programs with clear winners

38 signals on Catalio Nexus Fund IV

13 bullish · 3 contrarian · 10 pitch do's · 5 don'ts · 7 GP profiles, each with its source. From €9/month, cancel anytime.

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Facts

Fund Overview

Fund Size$400M

Saves0

Website

People

Key People

George Etrocheilos, Dr. Jacob Vogelstein

Wayne ShurtsAdvisory Board

Jonathan C. WilliamsAdvisory Board

Wesley StoryAdvisory Board

Ron AlfaCo-Founder & CEO

Lyn BaranowskiCEO

Mostafa ElSayedCo-Founder & CEO

Sri KosuriCo-Founder & CEO

N°04 / See also

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