Fund profile / United States

Breakout Ventures Fund III

Geography: United States
Stage: Seed
Fund size: $114M
Focus: AI/ML, Biotech and Deep Tech
Signals: Published

N°01 / About

About Breakout Ventures Fund III

San Francisco-based deep science VC. Fund III ($114M) backs seed-stage founders commercializing scientific breakthroughs with a focus on AI-enabled neuroscience and biology. LPs include JIMCO and Korea Omega Investment Corporation.

N°02 / Thesis

Investment Focus

Location / RegionUnited States

Funding StageSeed

Industry Focus

AI/ML

Biotech

Deep Tech

Investor Signals Profile

active

Sweet Spot

Scientist-founder building AI-accelerated platform in neurotech, drug discovery, or diagnostics

AI-enabled science

deep biotech

neuroscience

scientist-founders

platform discovery

Bullish Signals

Fund III freshly closed at $114M with institutional LPs JIMCO and Korea Omegablog

Surf Bio acquired by Halozyme up to $400M; Noetik GSK deal $50M upfront — real exitsblog

Neuroscience concentration positioned as earliest institutional call on new inflectionblog

Leads ~50% of rounds with $500K–$5M checks; takes double-digit equity positionsblog

Portfolio spans biotech, chem-tech, materials — broad science frontier coveragewebsite

Backs pre-company founders; open to pre-launch stagewebsite

Deep corporate & next-stage investor network for BD tractionwebsite

Portfolio includes carbon, gene therapy, biofabrication — frontier diversitywebsite

10+ years at science-tech frontier — rare institutional longevitywebsite

Embedded in markets founders need with corporate & strategic partner networkswebsite

Team has technical depth and commercial fluency to anticipate roadblockswebsite

Invest early with conviction; disciplined tailored approach to each companywebsite

Catalytic network drives traction and accelerates milestone achievementwebsite

Cytovale, Modern Meadow, Strm.bio, Ecovative — proven execution at frontierwebsite

Transformative companies unlock science power; expand frontier, create new marketswebsite

Portfolio now includes Epana Bio, ZymoChem, Twelve, Noetik — deepening portfoliowebsite

Contrarian Signals

Avoids AI for admin/workflow; rejects generic AI-bio positioning entirelyblog

Neuroscience has more failed funds behind it than almost any biotech sub-verticalblog

Modest $114M size is intentional — not competing with large multi-stage fundsblog

Wide thesis (bio, chem, materials) risks diluted focuswebsite

Pre-company bets increase execution risk at portfolio scalewebsite

Founder Do's

Come as a scientist-first founder with a defensible core scientific discovery

Target drug discovery, diagnostics, neurotech, materials science, or biomanufacturing

Be open to pre-seed or seed with no commercial PMF yet but strong scientific foundation

Highlight platform potential — acquirable and partner-valuable company architecture

Engage GPs at a technical peer level; they will go deep on the science

Founder Don'ts

Don't pitch AI tools for admin or workflow automation — explicitly out of scope

Don't come with software-wrapper-only business models dressed as deep tech

Don't expect a passive investor — Breakout leads ~50% of rounds and takes conviction positions

33 signals on Breakout Ventures Fund III

16 bullish · 5 contrarian · 5 pitch do's · 3 don'ts · 4 GP profiles, each with its source. From €9/month, cancel anytime.

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Facts

Fund Overview

Fund Size$114M

Saves0

Website

People

Key People

Lindy Fishburne, Julia Moore

Lindy FishburneManaging Partner

Julia MooreCo-Managing Partner

Nima RonaghiPartner

Dana WattPartner

Backers

Known LPs

JIMCO (Jameel Investment Management Company)Family office / Holding

Cortes CapitalFamily office / Holding

Korea Omega Investment CorporationPublic / State institution

+3 more LPs in LP Radar

N°04 / See also

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